CD22 Antikörper

Produktnummer ABIN400636

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD22 in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CD22 Antikörper (ABIN400636)

Target: CD22 (CD22 Molecule (CD22))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD22 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: IS7

Produktdetails anti-CD22 Antikörper

Kreuzreaktivität (Details): Species reactivity (tested):Human

Produktmerkmale: Synonyms: SIGLEC2, Siglec-2, B-cell receptor CD22, Leu-14, BL-CAM, Sialic acid-binding Ig-like lectin 2,B-lymphocyte cell adhesion molecule

Aufreinigung: Protein A affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Immunogen: Reh human cell line

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry. Positive control: lysed whole blood.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μm filter sterilized.

Konservierungsmittel: Azide free

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing andthawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD22

Target: CD22 (CD22 Molecule (CD22))

Andere Bezeichnung: CD22

Hintergrund: CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.Synonyms: B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Leu-14, SIGLEC2, Sialic acid-binding Ig-like lectin 2, Siglec-2

UniProt: P20273